The Monarch has recorded a intimate address regarding his journey with cancer, which will be broadcast as part of this year's fundraising initiative, spearheaded by medical research organisations and a major network.
Buckingham Palace said the King would talk about his "path to recovery" as a person living with the disease, in a video message on this Friday at the evening slot.
The address, taped inside Clarence House two weeks ago, will highlight the importance of preventative health checks to increase the likelihood more people detect the illness at an early stage.
This will be a rare update on the health of the Sovereign, who has been in a course of therapy since the news was shared in February 2024. Analysts suggest doubtful the King will disclose his specific form of cancer.
The Stand Up To Cancer event each year generates donations for medical research and treatment and urges people to get screenings to improve the chances of an early diagnosis.
The King's public discussion about his condition, and his experience as a patient, has been aimed to promote education and to persuade more people to get screened - and this will be taken a step further with this unique direct participation.
So far the King's key philosophy to his cancer has been to keep working, preserving a full diary alongside his frequent sessions of therapy, and he appears not to have wanted to be characterised by his illness.
Recently has seen the Sovereign, taking several international tours, such as visits to Italy and Canada, and hosting the highest tally of official guests to the UK for almost 40 years, featuring the German president in recent days.
This Friday's awareness broadcast on the network, presented by well-known figures like several TV personalities, will urge people not to be frightened of getting health screenings.
Each presenter have been affected by cancer - McCall revealed last month she had had an operation for a tumour, while Clare Balding was treated for the illness over a decade ago. Host Hills has previously mentioned his father, who had one form of cancer and then later blood cancer.
The broadcast will target the estimated 9m people in the UK who charities state are not current with national health programmes, with an online checker to let people see if they are able for screenings for key health indicators.
In an attempt to explain cancer checks and illustrate the benefit of prompt detection there will be a real-time transmission from cancer clinics at two Cambridge hospitals in Cambridge.
"My aim is to remove the anxiety out of health checks and demonstrate everyone that they are not isolated in this," commented Davina McCall.
At present in the UK, there are several key NHS cancer screening programmes - for bowel, breast and cervical cancer - offered to eligible individuals.
A new scheme for lung health is also being phased in for people at increased risk of contracting the condition, primarily aimed at people in a specific age bracket, who currently smoke or used to.
Men may discuss specific tests, but there is no national programme in place.
The Stand Up to Cancer campaign, which has collected over one hundred million pounds for many years, is financing dozens of clinical trials with thousands of patients.
The Monarch, in a message for guests at a gathering for support groups in earlier this year, had discussed recognising the "daunting and at times scary experience" for patients and their support networks.
But he said his personal journey of living with cancer had shown him that "periods of great challenge of illness can be brightened by the greatest compassion," as he commended those who looked after cancer patients.
The Palace has not made public the nature of cancer the King has, or what treatment he has undergone. The King's cancer was detected following he had received a prostate procedure.
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